Medical Health

April 29, 2007

How The Brain Copes With Shifty Eyeballs

Filed under: Medical News

Neurobiologists have pinpointed brain regions critical to one of the brain’s more remarkable feats - piecing together a continuous view of the world by integrating snippets of visual input from constantly moving eyes. Since the eyeball has only a narrow field of clear view, it must continually make tiny shifts to sample the visual world. And during these shifts, which last thousandths of a second, people are essentially blind.

Marvin Chun of Yale University and colleagues published their studies in the journal Neuron, published by Cell Press.

The researchers’ experiments with human volunteers used an illusion known as "boundary extension" to establish brain regions involved in piecing together scenes. In boundary extension, the brain tends to perceive more of a visual scene than is actually presented - a critical ability if the brain is to stitch together a continuous visual world from discontinuous snippets of a scene transmitted from the eyes.

The boundary extension illusion means that if people are presented with a close-up view of a scene followed by a wider view, they will not notice the difference. Their brains have already "assumed" the wider view, and they falsely remember it. On the other hand, people shown a wider view first will readily notice the appearance of the close-up view.

In their experiments, the researchers showed subjects paired scenes in which a close-up view was followed by a wider view, or in which a wider view was followed by a close-up view. They also showed the subjects paired scenes in which the same close and wider views were presented twice. The repeated pairs acted as controls to test whether only presentation of scenes would cause a response.

As the subjects were viewing the scenes, their brains were scanned using functional magnetic resonance imaging. In this technique, harmless radio waves and magnetic fields are used to image blood flow in brain regions, which reflects brain activity.

The researchers concentrated on two brain areas known to process visual information in scenes - the "parahippocampal place area" (PPA) in the medial temporal lobe and the "retrosplenial cortex" (RSC) in the cerebral cortex.

If these two areas are involved in extrapolating scenes, the researchers reasoned, they should see an attenuation of activity in these regions when subjects were presented with close-wide pairs, indicating that these brain areas were initially performing a boundary extension such that the close view was "remembered" as the wide view. In contrast, the PPA and RSC should show no attenuation of activity when presented with wide-close pairs. The researchers found that the two brain regions, indeed, showed activity patterns consistent with their involvement in the brain’s process of "extending" the scenes.

In contrast, another area of the brain involved in processing images of objects showed attenuation of activity in response to all of the scene pairs. That finding, said the researchers, showed that the processing of scenes does not extend to other brain areas responsible for processing objects or surfaces.

Chun and colleagues concluded that their findings "provide novel evidence that high-level visual mechanisms extrapolate spatial layout beyond the confines of a given view." They wrote that "Extrapolation of layout may thus provide a means by which the visual system can integrate discrete samples of surrounding space that are drawn from successive movements of the eyes and head, enabling perception of a richly detailed and continuous world."

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The researchers include Soojin Park, David Widders, and Marvin M. Chun of Yale University in New Haven, CT; Helene Intraub of University of Delaware in Newark, DE; Do-Joon Yi of Yonsei University in Seoul, Korea.

This work was supported by National Institutes of Health Grants to M.M.C. and to H.I., and Ministry of Science and Technology of the Republic of Korea 21st Century Frontier Research Program Brain Research Center grant to D.-J.Y.

Park et al.: "Beyond the Edges of a View: Boundary Extension in Human Scene-Selective Visual Cortex." Publishing in Neuron 54, 335-342, April 19, 2007. DOI 10.1016/j.neuron.2007.04.006. http://www.neuron.org/.

World Bank Board Discusses Official’s Attempt To Change Policy Promoting Family Planning In Madagascar, Los Angeles Times Reports

Filed under: Medical News

The World Bank Board of Directors reportedly met on Tuesday to discuss a bank official’s attempts to change policy promoting family planning in Madagascar, the Los Angeles Times reports (Gaouette, Los Angeles Times, 4/19). According to the public interest group the Government Accountability Project, one of the bank’s managing directors, Juan Jose Daboub, instructed several officials to delete all references to family planning from a proposal to curb poverty and disease in Madagascar. The proposal was a country assistance strategy, which is a long-term plan that outlines World Bank lending priorities. An internal e-mail made public by GAP — dated March 8 and originally sent by Lilia Burunciuc, Madagascar country program coordinator — said, "By the way, one of the requests received from the MD (Daboub) was to take out all references to family planning." It added, "We did that. However, this is a potential problem for us as the upcoming Health SWAP includes family planning measures in response to the government’s strong request for help in this area." Three bank staff members confirmed the authenticity of the e-mail. GAP also obtained a draft document of the bank’s Health, Nutrition and Population Strategy, which referred to family planning once in regard to a former bank program. The proposed HNP plan does not emphasize family planning or contraception as mentioned in the 1997 HNP plan, but it does say that bank-financed programs "will emphasize options for improving demand for reproductive health advice and services by strengthening female education, improving women’s economic opportunities and reducing gender disparities." The 1997 HNP highlighted restrictions to family planning services as a primary health challenge. Some staff said the proposed changes were widely viewed as a divergence from previous bank policy of promoting contraception for HIV prevention (Kaiser Daily Women’s Health Policy Report, 4/16).

Comments
Bank staff members said the Madagascar plan has been finalized and worry that other country plans might have been altered as well. Daboub said he would send at least 11 country reports, including Benin, Chad and Cameroon, to the board before December. In an e-mail to colleagues he wrote, "I respect the freedom of our partner countries to decide" on family planning. Bea Edwards, international director at GAP, said that scaling back family planning funding "would have a tremendous impact because the World Bank is a major lender in the health sector, particularly in the poorest countries." Some women’s health advocates said the situation is worrisome, the Times reports. "There’s mismanagement" at the World Bank, Carmen Barroso, regional director for the International Planned Parenthood Federation, said, adding that bank President Paul Wolfowitz appointed Daboub, "who felt free to censor in line with his personal beliefs," into a high level position. The board is scheduled to meet Thursday to discuss various issues, including the changes, the Times reports (Los Angeles Times, 4/19).

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

Jefferson Researchers Boost Immune ‘killer Cells,’ Increase Antibody Effectiveness Against Cancer

Filed under: Medical News

Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have devised a novel method to expand the number of immune system "natural killer (NK)" cells from blood cells outside the body. They have found that adding such cells to anti-cancer therapies involving monoclonal antibody drugs is more effective in killing cancer cells, and perhaps someday may improve treatments.

Reporting at the annual meeting of the American Association for Cancer Research in Los Angeles, scientists led by Takami Sato, M.D., K. Hasumi Associate Professor of Medical Oncology at Jefferson Medical College of Thomas Jefferson University showed in laboratory studies that adding such NK cells to a monoclonal antibody, Herceptin, which targets the HER2/neu protein on breast cancer cells, was more efficient at killing the cancer cells. The HER2/neu protein is expressed in approximately one-quarter of all breast cancers.

According to Dr. Sato, monoclonal antibodies help kill cancer cells by attaching to the cancer cell surface, in turn stimulating an outpouring of "effector" cells such as NK cells that attempt to neutralize the cancer. NK cells alone are often powerful cancer fighters, he notes, but NK cell function in cancer patients can be diminished, and chemotherapy can make things even worse.

Dr. Sato, international research study coordinator Mizue Terai, M.S., and their co-workers decided to try a different approach. They cultured peripheral blood mononuclear cells, which are a mixture of immune cells, including NK cells, for three weeks in the test tube with their novel technique. The resulting population of NK cells increased 500 to 1,000-fold. In subsequent experiments, they showed that the combination of NK cells and Herceptin was effective in killing HER2/neu-expressing breast cancer cells, though the effect depended on the amount of antibody.

They found that the expanded group of NK cells and antibody had little effect against breast cancer cells that did not express the HER2/neu protein.

"It [the results] doesn’t mean that the antibody and the NK cells will cure the cancer," Dr. Sato notes, "but it shows that using an antibody that recognizes the cancer cell along with added NK cells can be very effective against the tumor."

The researchers also found that the monoclonal antibody Rituxan greatly enhanced the cancer cell-killing ability of the expanded NK cells against another cancer cell line, B-cell lymphoma cell line. Rituxan is typically used in combination with chemotherapy to treat patients with B-cell non-Hodgkin’s lymphoma.

Dr. Sato says that the technique can be applied to "any cancer that has a monoclonal antibody available."

The team’s next step is to test the effectiveness of the added NK cells in an animal model. The group is also in the process of starting an early phase clinical study.

VA Walk-In Clinics Have Staff Shortages, Survey Finds

Filed under: Medical News

The number of combat veterans who return from the wars in Iraq and Afghanistan and visit Department of Veterans Affairs walk-in clinics has more than doubled since 2004, but the number of staff members at the clinics has increased by less than 10% over the same period, according to department records, USA Today reports. The clinics, called Vet Centers, are small, storefront buildings with four or five staff members. VA in 1979 established the clinics to help veterans who return from wars. The clinics provide services such as combat stress counseling, marriage therapy, job assistance and medical referrals. According to VA records, 21,681 veterans who returned from the wars in Iraq and Afghanistan visited the clinics in 2006, compared with 8,965 in 2004, and the number of staff members at the clinics increased to 1,063 from 992 over the same period. A VA survey of clinic team leaders nationwide found that 114 of the 209 clinics require at least one additional psychologist or therapist, but the department plans to increase the number of staff members at the clinics by only 61. In addition, the survey found that five clinics have waiting lists, and two have begun to substitute group counseling for more appropriate individual counseling because of staff shortages.

Comments
Al Batres, national director of Vet Center operations, said that he plans to fill staff shortages at the clinics over time. Batres said that the VA budget would allow for 23 additional Vet Centers to be built across the country by September 2008. In addition, Batres has hired 100 veterans who have returned from the wars in Iraq and Afghanistan to help educate new veterans about services available at the clinics. He said, "My task is to try to direct the right kind of services at the tight time to the right place." However, Joe Davis, a spokesperson for the Veterans of Foreign Wars, said, "The Vet Centers are on the front lines. Every one of the 200-plus Vet Centers are providing a vital service, but our greatest concern is five years from now, when more veterans and their families" visit the clinics (Zoroya, USA Today, 4/20).

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

First Systematic Study Of China’s One-Child Policy Reveals Complexity, Effectiveness

Filed under: Medical News

The first systematic examination of China’s fertility policy and practice reveals that, despite government exemptions in rural areas, 63 percent of Chinese couples are strictly limited to one child. Furthermore, the policy has proven remarkably effective, with actual birth rates decreasing nearly to the mandated levels.

The study, which involved researchers in the United States and China, is the first to use data on fertility policy and population growth collected from 420 Chinese prefectures (districts comparable to U.S. counties).

"We want to clear up confusion about the one-child policy," said Wang Feng, sociology professor at UC Irvine and a lead author of the study. "Despite what some say, the policy has not been ‘relaxed’ over the years."

Published in the current issue of the journal Population and Development Review, the study reveals the complexity of the one-child policy. For example, it details the kinds of exceptions within prefectures for couples who give birth to a girl first, and for parents who themselves come from a one-child family.

"The system of exemptions resembles the American tax code in its complexity," Wang said. "But this does not change the fact that the one-child policy applies without exception to a significant majority of Chinese couples."

China’s average mandated fertility rate, accounting for the variety of exceptions across the country, is 1.47 children per couple, Wang and his collaborators found, and their analysis of census data shows the actual fertility rate is about 1.5 children per couple.

"Such convergence between policy and reality is extraordinary, even for China," he said. "With the birth rate below replacement level, the country faces serious negative consequences in the long run if it fails to phase out the policy."

Wang, a demographer who has studied the one-child policy for more than a decade, notes that the law’s success is contributing to an increasing proportion of older Chinese citizens, a shrinking workforce, and a disproportionate number of males to females.

Except for the United States, most Western countries have below-replacement birth rates, due not to government regulations but to factors such as shifting family values and economic pressures, Wang says. He plans to explore how similar motives may affect birth rates in China, even for couples who legally can have a second or third child.

"No country has yet to reverse the trend of below-replacement birth rates, so China’s next step regarding its one-child policy will be an important one," Wang says. He notes that a plan to phase out the policy does not appear to be a government priority.

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Wang’s co-authors are Guo Zhigang from Peking University, Gu Baochang from Renmin University of China, and Zhang Erli, former Director of Statistics and Planning of the State Family Planning Commission of China.

Their research was funded by grants from the Ford Foundation and the John D. and Catherine T. MacArthur Foundation.

About the MacArthur Foundation: The John D. and Catherine T. MacArthur Foundation is a private, independent grant-making institution dedicated to helping groups and individuals foster lasting improvement in the human condition. With assets of more than $6 billion, the Foundation makes approximately $225 million in grants annually. More information is available at http://www.macfound.org/.

About the University of California, Irvine: The University of California, Irvine is a top-ranked university dedicated to research, scholarship and community service. Founded in 1965, UCI is among the fastest-growing University of California campuses, with more than 25,000 undergraduate and graduate students and about 1,800 faculty members. The second-largest employer in dynamic Orange County, UCI contributes an annual economic impact of $3.7 billion.

NBA Player, Actor Join U.N. Campaign To Curb HIV Stigma, Discrimination In China

Filed under: Medical News

The United Nations on Wednesday announced that National Basketball Association player Yao Ming, who was born in China, and Chinese film star Pu Cunxin have joined the "We Are Friends" campaign, a U.N. initiative to curb stigma and discrimination associated with HIV/AIDS in China, the AP/Dallas Morning News reports. Yao will be featured in posters that display the slogan, "HIV/AIDS will not affect our friendship." Yao in the poster will be standing with a group of children and signing autographs (AP/Dallas Morning News, 4/18). The campaign aims to promote the inclusion of HIV-positive people in workplaces, schools and families, Reuters reports. Allessandra Tisot, United Nations Development Programme senior deputy resident for China, said the United Nations "trust[s] this campaign will help disseminate our common stand for positive action, care and full integration of people live with HIV or AIDS in our global society" (Reuters, 4/18). As part of the campaign, more than 200,000 posters will be distributed throughout the country. In addition, a mini documentary will be distributed, and a resource kit, as well as other materials, will be developed. The posters will be printed in Chinese, as well as in the ethnic minority languages Tibetan, Uighur and Jingbo, according to the AP/Morning Post (AP/Dallas Morning Post, 4/18).

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

Abortion Does Not Increase Breast Cancer Risk, New Study Says

Filed under: Medical News

A new US study suggests that breast cancer risk is not increased by induced abortion or miscarriage, contrary to the findings of some other studies and the claims made by some groups.

The study is published in the Archives of Internal Medicine.

Researchers from Brigham and Women’s Hospital, Harvard Medical School and the Harvard School of Public Health, Boston in Massachusetts, used data from the Nurses’ Health Study II (NHS II) on 105,716 women who were aged between 29 and 46 years and cancer-free at the start of the ten-year follow-up which started in 1993.

The cohort is described by the researchers as "predominantly premenopausal", since most of the women had not started the menopause during the follow-up.

Records for the large scale prospective study were updated by questionnaire response every two years, and contained information on spontaneous abortions (miscarriages) and induced abortions, including any that had occurred before the period of study.

A large scale prospective study is considered high standard for this kind of research because you start with a large group of healthy participants and you monitor them for a good part of their lives to see who develops the symptoms under investigation.

This study covered 973,437 person-years of follow-up between 1993 and 2003.

(The number of person years of a study is an indication of its size and it is not unusual for researchers to talk about events per person year, which is the total number of events being counted divided by the total number of years of data from each participant.)

The results showed that:

– 1,458 new cases of invasive breast cancer occurred during the follow-up.
– 16,118 participants (15 per cent) reported a history of induced abortion.
– 21,753 (21 per cent) reported a history of spontaneous abortion (miscarriage).
– Neither abortion nor miscarriage was linked significantly with breast cancer.
– The results were unaffected by number of abortions or miscarriages, age of woman when the events occurred, and other factors.

In summary, the researchers found no significant link between abortion, miscarriage and breast cancer across the group. However, they did report two subgroup effects.

One subgroup showed a link between induced abortion and progesterone receptor-negative breast cancer, the kind of cancer that does not respond to the hormone progesterone.

The other subgroup showed a link between miscarriage before the age of 20 and lower breast cancer risk.

But in both cases the researchers suspect the results are spurious, due to chance, because the numbers in the two groups are too low to give a confident statistical finding.

Their overall conclusion therefore was that:

"Among this predominantly premenopausal population, neither induced nor spontaneous abortion was associated with the incidence of breast cancer."

About the Nurses’ Health Study II (NHS II)

The NHS II is a prospective study cohort of over 116,000 women enrolled in 1989.

The purpose of the NHS II study is to look at the link between potentially modifiable risk factors and any major health problems that arise among women in early adult life. Breast cancer and melanoma are two particular areas of interest to the researchers.

The participants fill in questionnaires about their lifestyle, dietary habits, life events, exercise, use of contraceptives, and health issues every two years.

Adverse health events such as cancer diagnosis are followed up with more detailed investigation of medical records, and blood samples are analysed from about 30,000 of the cohort.

90 per cent response rate has been maintained for the questionnaire follow-ups.

To Grow Your Kids’ Desire For Vegetables And Fruit, Plant A Garden

Filed under: Medical News

If you are looking for a way to encourage your children eat their fruits and vegetables, search no further than your backyard, suggests new Saint Louis University research.

Preschool children in rural areas eat more fruits and vegetables when the produce is homegrown.

"It was a simple, clear finding," said Debra Haire-Joshu, Ph.D., director of Saint Louis University’s Obesity Prevention Center and a study author. "Whether a food is homegrown makes a difference. Garden produce creates what we call a ‘positive food environment’."

Researchers interviewed about 1,600 parents of preschool-aged children who live in rural southeast Missouri. They found that preschool children who were almost always served homegrown fruits and vegetables were more than twice as likely to eat five servings a day than those who rarely or never ate homegrown produce.

The American Dietetic Association recommends between five and 13 servings of fruits and vegetables a day.

In addition, children who grow up eating fresh-from-the-garden produce also prefer the taste of fruits and vegetables to other foods, the parents told researchers.

The study, in the April issue of the Journal of the American Dietetic Association, found the garden-fed children were more likely to see their parents eating fruits and vegetables.

A greater variety of fruits and vegetables - more tomatoes, cantaloupe, broccoli, beans and carrots - also were available in the homes of families who nearly always had homegrown produce.

The implications of the research are important because they point to a simple way of getting kids to eat healthier, Haire-Joshu said. Plant a garden or encourage your school to do so.

"When children are involved with growing and cooking food, it improves their diet," Haire-Joshu said. "Students at schools with gardens learn about math and science and they also eat more fruits and vegetables. Kids eat healthier and they know more about eating healthy. It-s a winning and low-cost strategy to improve the nutrition of our children at a time when the pediatric obesity is an epidemic problem."

Editorials, Opinion Pieces Respond To U.S. Supreme Court Ruling Federal Abortion Ban Constitutional

Filed under: Medical News

Several newspapers recently published editorials and opinion pieces about the Supreme Court’s 5-4 ruling on Wednesday to reinstate a federal law banning so-called "partial-birth" abortion, overturning the rulings of three appeals courts. Chief Justice John Roberts and Justices Samuel Alito, Clarence Thomas and Antonin Scalia joined Justice Anthony Kennedy in the majority opinion and Justices Stephen Breyer, John Paul Stevens and David Souter joined Justice Ruth Bader Ginsburg in the dissent. President Bush signed the Partial-Birth Abortion Ban Act (S 3) into law in November 2003. The Planned Parenthood Federation of America, the American Civil Liberties Union on behalf of the National Abortion Federation, and the Center for Reproductive Rights on behalf of four abortion providers filed lawsuits alleging that the law is unconstitutional because of the absence of an exception for procedures preformed to protect the health of the pregnant woman. In place of a health exception, the law includes a long "findings" section with medical evidence presented during congressional hearings that, according to supporters of the law, indicates the procedures banned by the law are never medically necessary. The law says a physician who performs the banned procedures could face criminal prosecution, fines and up to two years in jail. The law allows an exception for cases in which the life of the woman is in danger, but it does not permit doctors to use the procedure because they believe using another method would increase risks to the woman’s health. Federal judges in California, Nebraska and New York each issued temporary restraining orders to prevent enforcement of the ban, and appellate court panels upheld the rulings (Kaiser Daily Women’s Health Policy Report, 4/19). Summaries appear below.

Editorials

    * Albany Times-Union: The Supreme Court has "made an assertion that few lawmakers are qualified to make, that partial-birth abortion is never medically necessary," a Times-Union editorial says. "The determination of a majority of the court to go to considerable lengths to restrict the legality and availability of abortion is clear enough," the editorial says, adding that political and judicial "bodies should not be making medical judgments" (Albany Times-Union, 4/19).

    * Boston Globe: Lawmakers who passed the 2003 partial-birth abortion ban and the five justice majority that upheld the law "have overruled the best judgment of the doctors who are most informed on this issue," a Globe editorial says. The Globe added, "Politics could trump medicine again — unless backers of abortion rights use the ballot box to steer the country back toward support of a woman’s right" to choose (Boston Globe, 4/19).

    * Boston Herald: All "but the most pro-choice zealots can live with" the ruling, a Herald editorial says, adding that politicians "who will attempt to leverage" the ruling for "political gain" will "do so at an enormous risk to their credibility." According to the Herald, there is "near universal agreement" that the procedures banned by the law are "abhorrent" (Boston Herald, 4/19).

    * Chicago Tribune: Congress could have "accommodated the legitimate interests" of both sides of the debate on partial-birth abortion if it had specified that the procedures "should be used only when it is essential to prevent serious harm" to the pregnant woman, a Tribune editorial says. "Congress and the court have taken the view that a ban on partial-birth abortion won’t make women less safe," the Tribune says, concluding, "Even critics of this decision will be hoping they’re right" (Chicago Tribune, 4/19).

    * Denver Post: Although the ruling does "not signify the imminent reversal of Roe," there is a "broader concern about how the court’s new activist majority is lining up," a Post editorial says, concluding that it is "essential that this court remain true to the important rights confirmed by its predecessors" (Denver Post, 4/19).

    * Detroit Free Press: The "immediate effect" of the court’s decision might be a "small erosion of abortion rights," a Free Press editorial says. However, the ruling could "inspire" legislators who oppose abortion rights to "be more aggressive" in their future efforts to restrict the procedure and "make it more difficult for abortion-rights groups to rebuff their advances," according to the editorial (Detroit Free Press, 4/19).

    * Long Island Newsday: The court’s ruling is "unconscionable" and "troubling," and it allows Congress to "play doctor" in "negotiating the challenging ethical terrain of late-term abortions," a Newsday editorial says. Although the court "left the door open a crack" that allows for challenges to the ban on a case-by-case basis, that is "cold comfort for a woman in immediate peril or for doctors who risk going to prison for doing what’s safest for their patients," the editorial concludes (Long Island Newsday, 4/19).

    * Los Angeles Times: The court made an "unconscionable U-turn on abortion, upholding a restrictive federal law that is virtually indistinguishable from a Nebraska statute it struck down only seven years ago," a Times editorial says. Although the "muddled" decision will have no effect on the "vast majority of abortions" performed in the U.S., the ruling represents a "retreat" from precedent that can only be explained by changes to the court’s membership, the editorial concludes (Los Angeles Times, 4/19).

    * New York Daily News: The ruling, which is "more an expression of moral revulsion than a respectful parsing of precedents," has made "less absolute a woman’s right to choose," a Daily News editorial says. Roberts and Alito "demonstrated a willingness to depart from precedent where it suits them," which is "not how you want the Supreme Court to conduct business," the editorial says, adding, however, the "majority did at least reach a position on abortion that most Americans will likely support" (New York Daily News, 4/18).

    * New York Times: The "atrocious" ruling "gutted a host of thoughtful lower court rulings" and Supreme Court precedent, as well as "severely eroded the constitutional respect and protection accorded to women and the personal decisions they make about pregnancy and childbirth," a Times editorial says. According to the Times, the court has handed the Bush administration and other abortion-rights opponents a "big political victory" at a "real cost to the court’s credibility, its integrity and the rule of law" (New York Times, 4/19).

    * San Jose Mercury News: The majority of the Supreme Court is "willing … to put women’s lives in jeopardy in the midst of an already horrific set of circumstances," a Mercury News editorial says, adding that the decision will "pav[e] the way for abortion opponents to seek bans on other procedures." The Mercury News says that voters "must elect leaders who will overthrow this law and respect American women’s right to choose" (San Jose Mercury News, 4/19).

    * San Francisco Chronicle: Although the court’s decision is "not a surprise, given the conservative composition of the court," that "does not make it any less of an outrage," a Chronicle editorial says. "Buried beneath all of this noise" surrounding the abortion debate are the "millions of American women who have been faced with one of the most difficult decisions of their lives and the doctors who should be free to provide them with the safe, private care that their experience and judgment has shown to be best," the editorial concludes (San Francisco Chronicle, 4/19).

    * Seattle Post-Intelligencer: The court’s ruling appears to support "several misguided notions," including that "abortions are lifestyle choices," that legislators "know better than doctors and individuals" about the procedure and that partial-birth abortion "doesn’t exist out of medical necessity but out of some cruel need to abort a fetus in the most savage way possible," a Post-Intelligencer editorial says. The editorial adds that the law "robs an individual of the right to make an autonomous choice" and prevents physicians from providing "the best possible care for their patients" (Seattle Post-Intelligencer, 4/18).

    * USA Today: By upholding a ban on partial-birth abortion, the Supreme Court "reached deeply into women’s lives and took away one medical option they have had to deal with such a wrenching decision" as terminating a pregnancy, a USA Today editorial says. The editorial adds that the ruling "takes the court in a troubling new direction, one that will harm some women or limit their ability to deal with a profoundly personal decision" (USA Today, 4/19).

    * Wall Street Journal: The Supreme Court’s decision "has shown a very modest new deference to the will of the voters on abortion, but no more," a Journal editorial says. According to the Journal, the ruling sends the debate back to the states, which "is all to the good" because "the best place to settle abortion disputes is in state legislatures, where a political consensus that better reflects public opinion can be struck" (Wall Street Journal, 4/19).

    * Washington Post: The court’s decision is not "apt to prevent any abortions," a Post editorial says, adding it is more likely that the "tiny percentage of women who would have undergone this admittedly gruesome procedure will instead opt to terminate their pregnancies by another procedure, equally, if not more, gruesome" (Washington Post, 4/19).

    * Washington Times: The ruling is a "victory for commonsense morality and for constitutional jurisprudence" and "is proof that under the Roberts court, careful abortion restrictions can begin to shift the law from the abortion-on-demand regime enacted in 1973 to one that better reflects public opinion and morals," a Times editorial says. The editorial added that by enacting the law, Congress enacted "the will of the people previously frustrated by the courts" and advocacy groups (Washington Times, 4/19).

Opinion Pieces

    * Ellen Goodman, Boston Globe: "How many times must it be said that those who support a woman’s right to decide want abortion to be safe, legal and rare?" Globe columnist Goodman writes in an opinion piece. Goodman adds that with the Supreme Court decision, "women whose pregnancies come with alarming words and dangerous diagnoses live in a world that is a little less legal and a lot less safe" (Goodman, Boston Globe, 4/20).

    * Judy Climer, Detroit Free Press: The ruling bans a "cruel and gruesome procedure" and is a "monumental victory for the protection of defenseless human life," Climer, president of Flint Area Right to Life and Genesee County Black Americans for Life, writes in a Free Press letter to the editor (Climer, Detroit Free Press, 4/20).

    * Cass Sunstein, Los Angeles Times: Ginsburg in her dissenting opinion "offered the most powerful understanding of the foundations of the right to choose," Sunstein of the University of Chicago Law School writes in a Times opinion piece. According to Sunstein, it is "important to remember that today’s dissenting opinion often becomes tomorrow’s majority" (Sunstein, Los Angeles Times, 4/20).

    * Joan Malin, New York Times: The court’s decision is a "stunning assault on women’s health and rights," Malin, president and CEO of Planned Parenthood of New York City, writes in a Times letter to the editor. She adds, "Americans should be outraged that the Supreme Court turned women’s health concerns over to politicians, as they inserted themselves into our most private medical decisions" (Malin, New York Times, 4/20).

    * Deborah Oyer, New York Times: The court’s decision "insidiously injects government into the personal decisions a woman makes with her physician," Oyer, a board member of the National Abortion Federation, writes in a Times letter to the editor. She adds that the decision is an "insult to a woman’s right to protect her own health and to a physician’s ability to advise her" (Oyer, New York Times, 4/20).

    * Edward Whelan, USA Today: The ruling offers "some hope" that the "radical regime of unrestricted abortion" the court "impose[d]" in the Roe decision, Whelan, president of the Ethics and Public Policy Center, writes in a USA Today opinion piece. According to Whelan, the five justices in the majority "exercised judicial restraint and properly deferred to the democratic process" (Whelan, USA Today, 4/19).

Broadcast Coverage

    * CBS’s "Evening News": The "Evening News" on Thursday reported on reaction to the ruling from abortion-rights supporters and opponents. The segment includes comments from Nancy Northup, president of CRR, and Jay Sekulow, chief counsel for the American Center for Law and Justice (Andrews, "Evening News," CBS, 4/19). Video of the segment is available online.

    * NBC’s "Nightly News": The "Nightly News" on Thursday reported on reaction at the state level. The segment includes comments from Missouri state Rep. Cynthia Davis (R); Kelli Conlin of NARAL Pro-Choice America; and Leslie Rottenberg, director of an abortion clinic (Fratangelo, "Nightly News," NBC, 4/19). Video of the segment is available online.

    * KCRW’s "To the Point": The program on Friday is scheduled to include a discussion about the ruling, among other topics ("To the Point," KCRW, 4/20). Additional information about the segment available online. Audio of recent broadcasts are available online.

    * NPR’s "All Things Considered": "All Things Considered" on Thursday reported on reaction from physicians. The segment includes comments from Deborah Oyer, director of a Seattle abortion clinic; Douglas Johnson, legislative director of the National Right to Life Committee; and Nancy Stanwood, an assistant professor of obstetrics and gynecology at the University of Rochester (Rovner, "All Things Considered," NPR, 4/19). Audio and a partial transcript of the segment are available online.

    * NPR’s "Day to Day": "Day to Day" on Thursday reported on reaction from presidential candidates. The segment includes comments from Richard Land of the Southern Baptist Convention; Nancy Keenan, president of NARAL Pro-Choice America; and Bill Galston, a domestic policy official during the Clinton administration (Liasson, "Day to Day," NPR, 4/19). Audio of the segment is available online. The program also included a discussion with Karen Lifford, director of the Planned Parenthood League of Massachusetts, about abortion methods (Brand, "Day to Day," NPR, 4/19). Audio of the segment is available online.

    * NPR’s "News & Notes": The program on Thursday included a roundtable discussion about the ruling, among other topics. Panelists included Walter Fields, a political consultant; Ron Christie, vice president of D.C. Navigators; and Julianne Malveaux, president of Last Word Productions (Chideya, "News & Notes," NPR, 4/19). Audio of the segment is available online.

    * PBS’ "Washington Week": The program on Friday is scheduled to include a discussion with Linda Greenhouse, a Supreme Court reporter for the New York Times (Greenhouse, "Washington Week," PBS, 4/20). Additional information about segment is available online. A transcript of the segment will be available online Monday. Video of the segment will available online Friday after 11:00 p.m.

    * washingtonpost.com: Washington Post Supreme Court reporter Robert Barnes on Thursday discussed the ruling in an online chat (Barnes, washingtonpost.com, 4/19). A transcript of the chat is available online.

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

Highlighted Sessions Of ASBMB’s 2007 Annual MeetingHighlighted Sessions Of ASBMB’s 2007 Annual Meeting

Filed under: Medical News

The 2007 annual meeting of the American Society for Biochemistry and Molecular Biology (ASBMB) will feature the latest news about cell biology, signaling pathways, and genome dynamics, with 156 presentations in over 50 sessions. The meeting will also include award lectures and sessions on educational and professional development, minority affairs studies, and the interplay between the biomedical sciences and public policy. The meeting will take place at the Washington Convention Center, 801 Mt. Vernon Place, NW, Washington, D.C., from April 28 to May 2.

The ASBMB meeting will be part of a multi-society meeting called Experimental Biology 2007 (EB 2007), which also includes the annual meetings of the American Association of Anatomists, the American Physiological Society, the American Society for Investigative Pathology, the American Society for Nutrition, and the American Society for Pharmacology and Experimental Therapeutics.

More information about the meeting, including a list of all sessions

Brief descriptions of highlighted sessions follow. The times indicated below may vary depending on the time taken by preceding presentations.

SUNDAY, APRIL 29

Topic: Treatment for Depression
Session: Science at Undergraduate Institutions
Time/Location: 4:35 p.m.-5:05 p.m., Room 209C
Title: "Tricyclic Antidepressants, but not the Selective Serotonin Reuptake Inhibitor Fluoxetine, Bind to S1S2 Domain of AMPA Receptors"

Topic: Receptor Tyrosine Kinases and Cancer
Session: Cytokine and Growth Factor Signaling
Time/Location: 5:20 p.m.-5:50 p.m., Room 202A
Title: "Cell Signaling by Receptor Tyrosine Kinases: From Bench to Bedside"
Summary: JOSEPH SCHLESSINGER, William H. Prusoff Professor and Chair of Pharmacology at Yale University, New Haven, Conn., will present the latest research on a family of cell-surface receptors called receptor tyrosine kinases and their role in causing cancers, developmental abnormalities, severe bone disorders, and immune diseases. Schlessinger will show how this research has led to new drugs that block the actions of several tyrosine kinases. He will also describe a new approach for the development of cancer drugs.

MONDAY, APRIL 30

Topic: Protein Biosynthesis
Session: Molecular Mechanisms of Protein Biosynthesis
Time/Location: 10 a.m.-10:30 a.m., Room 209A
Title: "Insights from Global Studies of Eukaryotic Translation"
Summary: DANIEL HERSCHLAG, Professor of Biochemistry at Stanford University, Calif., will describe how, by using the yeast genome, he and colleagues revealed new details of how proteins are made in yeast.

Topic: Sickle Cell Anemia
Session: Genetic Diseases in Minority Populations - Sickle Cell Anemia
Time/Location: 10:55 a.m.-11:35 a.m., Room 209C
Title: "Iron Overload and Sickle Cell Anemia: Monitoring and Treatment"
Summary: Sickle cell anemia, a disease in which the red blood cells change shape, thus depriving tissues of oxygen and causing heart disease and stroke, affects about 70,000 people in the United States, most of them of African descent. JANE HANKINS, Faculty Assistant Member at St. Jude Children’s Research Hospital, Memphis, Tenn., will discuss iron overload resulting from repeated blood transfusions in sickle cell anemia and how to best monitor and treat this complication.

Topic: Enzyme Dynamics
Session: The Role of Dynamics in Enzyme Catalysis
Time/Location: 11:15 a.m.-11:45 a.m., Room 207B
Title: "Single Molecule Studies of Enzyme Dynamics and Mechanisms"
Summary: GORDON G. HAMMES, Distinguished Service Professor of Biochemistry at Duke University, Durham, N.C., will discuss the potential of a recent technique called single molecule fluorescence microscopy, which provides fresh insight into how enzymes work. Unlike other techniques that look at the average behavior of many millions of molecules, single molecule fluorescence microscopy studies single molecules, thus revealing information that may be lost in the averaging process.

Topic: National Institutes of Health’s Funding Policy
Session: Public Affairs Advisory Committee-Sponsored Symposium
Time/Location: 12:45 p.m.-1:45 p.m., Ballroom C
Title: "NIH at the Crossroads: How Diminished Funds Will Impact Biomedical Research and What Scientists Can Do About It"
Summary: ELIAS ZERHOUNI, Director of the National Institutes of Health (NIH), will provide details on the current state of the NIH enterprise and offer projections based on the Fiscal Year 2008 budget. Hon. JOHN PORTER, former Chair of the U.S. House of Representatives’ Appropriations Subcommittee on Health and Human Services and Labor, will provide a legislative overview of the Fiscal Year 2008 outlook for the NIH and will discuss how scientists could become politically active and make suggestions for what needs to be done to make an impact on the NIH budget.

Topic: Mitochondrial Decay and Neurodegeneration
Session: Mitochondrial Dynamics
Time/Location: 3:35 p.m.-4:05 p.m., Room 207A
Title: "Mitochondrial Dynamics and Neurodegeneration"
Summary: DAVID C. CHAN, Principal Investigator at California Institute of Technology, Pasadena, will describe how the dysfunction of mitochondria in neurons can lead to a neurodegenerative disease called Charcot-Marie-Tooth disease. In particular, he will show the role of mitochondrial proteins called microfusins in this disease.

Topic: Drug-Resistant Bacteria
Session: Antibiotics for the 21st Century
Time/Location: 5:15 p.m.-5:50 p.m., Room 202A
Title: "The Evolution of Antibiotic Resistance"
Summary: Bacteria have developed resistance to most of the currently used antibiotics. FLOYD ROMESBERG, Associate Professor of Chemistry at the Scripps Research Institute, La Jolla, Calif., will present research efforts that seek to inhibit the bacterial mutations that allow bacteria to become drug-resistant. This work could lead to a new way of preventing the evolution of antibiotic resistance in bacteria.

Topic: Neurodegenerative Diseases
Session: Conformational Transitions and Protein Aggregation
Time/Location: 5:20 p.m.-5:50 p.m., Room 207B
Title: "Understanding and Ameliorating Age-Onset Neurodegenerative Diseases"
Summary: JEFFERY KELLY, Lita Annenberg Hazen Professor of Chemistry at Scripps Research Institute, La Jolla, Calif., will discuss how misfolding and/or misassembly of intracellular proteins causes neurodegenerative diseases such as Huntington’s and Parkinson’s diseases, whereas extracellular misfolding and/or misassembly appears to cause diseases known as amyloidoses, which includes Alzheimer’s and rare familial disorders. Kelly will also show how our current understanding of these disorders can lead to new therapeutic strategies.

TUESDAY, MAY 1

Topic: HIV and Hepatitis C
Session: Infectious Diseases in Minority Populations - Hepatitis C
Time/Location: 11:10 a.m.-11:45 a.m., Room 209C
Title: "HIV and HCV Infection among Minority Drug Injectors"
Summary: Injection drug users are at increased risk for acquiring and transmitting HIV and Hepatitis C virus (HCV), potentially increasing infection rates in minority communities. ANTONIO ESTRADA, Director of Mexican American Studies and Research Center and Professor of Public Health in the Mel and Enid Zuckerman College of Public Health at The University of Arizona, Tucson, will discuss the institutional, financial, and social obstacles to reduce HIV and HCV infection in minority communities.

Topic: Living Longer by Eating Less
Session: Aging and Metabolism
Time/Location: 4:20 p.m.-4:50 p.m., Room 207A
Title: "Calorie Reduction and Life Span Extension: A Genetic Pathway in the Fly"
Summary: Previous studies have shown that worms, fruit flies, and mice that are forced to eat less than their average daily diet can expand their life span significantly. STEPHEN L. HELFAND, Professor of Genetics and Developmental Biology at Brown University, Providence, R.I., will present new data in fruit flies showing that this life span extension may have a genetic origin, meaning that only animals with the right genes may be able to live longer by eating less.

WEDNESDAY, MAY 2

Topic: Integrins and Cancer
Session: Extracellular Matrix at the Organism Scale
Time/Location: 10 a.m.-10:40 a.m., Room 202B
Title: "The Role of the Alpha-2 Beta-1 Integrin in the Tumor Microenvironment"
Summary: MARY M. ZUTTER, Professor of Pathology at Vanderbilt University School of Medicine, Nashville, Tenn., will discuss the role of a cell membrane receptor called alpha-2 beta-1 integrin in regulating the growth of cancer cells.

Topic: Tuberculosis
Session: Infectious Diseases in Minority Populations - Tuberculosis
Time/Location: 10:45 a.m.-11:30 a.m., Room 209C
Title: "The Role of Resuscitation-Promoting Factors in the Virulence of Mycobacterium tuberculosis" Summary: One-third of the world’s population is infected with a dormant form of Mycobacterium tuberculosis - the bacterium that causes tuberculosis. These bacteria can lay dormant inside people and may not become active until decades later. BAVESH KANA, a researcher at the University of the Witwatersrand, Johannesburg, South Africa, will present new research that could explain how the bacteria awake from this dormant state to cause disease.

Topic: Proteomics and Human Health
Session: Proteomics of Cell Systems
Time/Location: 2:20 p.m.-2:50 p.m., Room 202B
Title: "Proteomics for Elucidating Protein Function, Regulatory Networks, and Improving Human Health" Summary: Although the sequencing of entire genomes has provided significant information, current and future challenges will be to identify the functions of the proteins made by these genes. MICHAEL SNYDER, Associate Professor of Molecular Biophysics and Biochemistry at Yale University, New Haven, Conn., will describe novel techniques he and his colleagues have developed to determine protein function in yeast and humans.

Topic: Cell Membrane Proteins
Session: Specific Protein-Lipid Interactions
Time/Location: 3:05 p.m.-3:35 p.m., Room 201
Title: "Translocon-Assisted Folding of Membrane Proteins: New Insights into Lipid-Protein Interactions" Summary: STEPHEN WHITE, Professor of Physiology and Biophysics at the University of California at Irvine, will provide new details about how proteins are put together on a cell’s membrane with a help of a tunnel-like protein complex called translocon.

Topic: RNA Editing
Session: RNA Modification: Mechanism and Function
Time/Location: 4 p.m.-4:35 p.m., Room 209A
Title: "Fine Tuning of Behavior by RNA Editing"
Summary: Before being used to produce proteins, messenger RNA is "recoded" or "edited" by an enzyme called Adenosine Deaminase Acting on RNA (ADAR). ROBERT REENAN, Professor of Biology at Brown University, Providence, R.I., will show that the presence of edited proteins is necessary for normal adult brain function and that the lack of edited proteins originating from a single gene results in subtle defects in complex behaviors.

Topic: Unlinking DNA
Session: Chromosome Segregation and Aneuploidy
Time/Location: 4:05 p.m.-4:35 p.m., Room 206v Title: "RanBP2/Nup358 Is Required for Topoisomerase II/alpha-Mediated DNA Decatenation, Proper Chromosome Segregation and Tumor Suppression"
Summary: Topoisomerases are proteins that unlink DNA in chromosomes when a cell divides. JAN M. VAN DEURSEN, Professor of Biochemistry and Molecular Biology at Mayo Clinic, Rochester, Minn., will discuss topoisomerase II/alpha’s role in cell division and show that a protein involved in transporting proteins between the nucleus and the cell’s cytoplasm is also helping topoisomerase II/alpha.

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